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bupropion facts from trusted sources:
Three metabolites have been shown to be active: hydroxyBupropion, which is formed via hydroxylation of the tert-butyl group of Bupropion, and the amino-alcohol isomers threohydroBupropion and erythrohydroBupropion, which are formed via reduction of the carbonyl group. While the mechanism of action of Bupropion, as with other antidepressants, is unknown, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms. 5%, a finding consistent with the extensive metabolism of Bupropion. They were randomly assigned to use a nicotine patch for 10 weeks or a combination of a patch, a nicotine oral inhaler and bupropion for as long as required. The elimination half-life of hydroxyBupropion is approximately 20 (±5) hours, and its AUC at steady state is about 17 times that of Bupropion. At least 14 days should elapse between discontinuation of an MAO inhibitor and initiation of treatment with bupropion hydrochloride.
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